Osmotic (RBC) Fragility Test

2 Parameters

Also called: RBC Fragility Test, OFT, Osmotic Fragility

Commonly prescribed for: Hereditary spherocytosis, hemolytic anemia of unknown origin, red blood cell membrane defect evaluation, splenomegaly workup

Home Collection

Report Delivery: Sample before 12 PM → by 8:30 PM today Sample after 12 PM → by 1 PM tomorrow

Call for Support

Age Group

All Ages

Sample Required

Peripheral Blood

Test For

Men, Women

Contains

2 Tests

Tests available at

Home Collection

Preparations

Fasting for 8-12 hours preferred

Expert Analysis

Case Studies

16 Jan, 2025

12 Minutes

Clinical Significance: The Osmotic Fragility Test measures red blood cell resistance to hemolysis under decreasing saline concentrations, diagnosing hereditary spherocytosis and erythrocyte membrane fragility.

Why It's Done:

Evaluate structural integrity and surface-area-to-volume ratio of red blood cells

Confirm spherocytic RBC hemolysis at higher saline concentrations than normal cells

Differentiate hereditary spherocytosis from autoimmune hemolytic conditions

Guide decisions regarding splenectomy in chronic hemolytic patients

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Tapadia Diagnostic

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